Among the films crew is cinematographer Aldo Tonto who had worked with Federico Fellini and Roberto Rossellini.

[2] Morricone and Nicolai's score was re-worked music from the 1968 TV show Musica da sera.

[2] Roma come Chicago was shot at De Laurentiis studios and on location in Rome.

[1] Director Alberto De Martino discussed the film's location as an "Americanized Rome".

[2] Roma come Chicago was released in Italy on 20 November 1968 where it was distributed by Paramount – De Laurentiis.