The Roman Catholic Archdiocese of Regina (Latin: Archidioecesis Reginatensis) is a Roman Catholic archdiocese comprising the southern part of the Canadian province of Saskatchewan, as far north as the 30th township, or about 51°30' lat.

The metropolitan province includes the suffragan dioceses of Prince Albert and Saskatoon.

Its current archbishop, Donald Bolen, and staff now serve nearly 124,000 parishioners living in 158 parishes and missions scattered over more than 155,000 square kilometres in southern Saskatchewan.

This extraordinary Romanesque building was built with an interior large enough to welcome parishioners and clergy from across southern Saskatchewan for special Masses, ordinations, funerals, weddings, and installations of archbishops.

In 1998, the former Diocese of Gravelbourg was merged with the archdiocese, with its former cathedral now designated Our Lady of Assumption Co-Cathedral.