In 1223, after the 1187 fall of the crusader Kingdom of Jerusalem in Palestine to Ayyubid Sultan Saladin, the Bishop Rainiero (a Cistercian) took residence in Clamecy.
The Dominican Guillaume (instated 1331) probably was the last incumbent of Bethlehem to set foot in his 'original' Palestinian diocese, where he hoped to restore the basilica (raising significant funds) and may have died (1346?47).
During the long-standing Papal schism (from 1378), Clamecy had two rivaling series of Bishops from 1379 to 1422 : those loyal to Rome, hence canonical, but in Italian (double) exile, where they could only collect revenues from the see's Italian possessions, and schismatical pretenders, who however took actual possession in (after all French) Burgundy in the name of Antipopes at Avignon (Clement VII and Benedict XIII) or Pisa (Alexander V and John XXIII).
Especially the Diocese of Auxerre and other neighbor sees kept contesting Clamecy's spiritual and canonical jurisdiction, and of course its benefices, seeking recourse in lawsuits, notably with the (regional) parliament (feudal appellate court) on 22 February 1674 and the general assembly of the French clergy on 27 August 1770.
In the second half of the 16th century, they see remained vacant as the nominees of the Dukes of Nevers (by royal delegation) were refused papal confirmation.