The diocese of Cần Thơ (Latin: Dioecesis Canthoënsis) is a Roman Catholic diocese of Vietnam.

The creation of the diocese in present form was declared November 24, 1960.

The diocese covers an area of 13,257 km2 (5,119 sq mi), and is a suffragan diocese of the Archdiocese of Ho Chi Minh city.

By 2004, the diocese of Cần Thơ had about 176,424 believers (3% of the population), 153 priests and 131 parishes.

This article on a Roman Catholic diocese in Vietnam is a stub.