The Diocese of Caguas (Latin: Dioecesis Caguana) is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in southeastern Puerto Rico in the United States.

It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Juan de Puerto Rico The mother church of the Diocese of Caguas is the Catedral Dulce Nombre de Jesús (Cathedral of the Sweet Name of Jesus) in Caguas.

As of 2023, the current bishop of Cagus is Eusebio Ramos Morales.

The diocese was erected on November 4, 1964 The Diocese of Caguas includes the following municipalities: Naranjito, Barranquitas, Comerío, Aguas Buenas, Caguas, Gurabo, Aibonito, Cidra, Cayey, San Lorenzo, Juncos, Las Piedras, Yabucoa, and Maunabo.

[1] On 7 September 2018, Judge Edward Godoy ruled that the bankruptcy filed by the Archdiocese of San Juan would also apply to every Catholic diocese in Puerto Rico, including Caguas, and that all would now have their assets protected under Chapter 11.