The Roman Catholic Diocese of Comodoro Rivadavia encompasses 234,000 km² (90,382 Square Miles) of central Patagonia covering the Province of Chubut.

In 1961, its southern half became the separate Diocese of Río Gallegos.

In 2009, part of the diocese became the Territorial Prelature of Esquel.

The Cathedral is located in the city of Comodoro Rivadavia.

In 2024 the Apostolic Administrator, bishop Roberto Álvarez, described the religious landscape of Patagonia as mission territory.