From 1891 to 1914, the El Paso area was taken from the Vicariate Apostolic of Arizona and divided between the newly formed Dioceses of Dallas, San Antonio and Tucson.

After taking heavy losses in Santa Fe, the Spanish were able to flee with many of their Native American enslaved people to the El Paso Valley.

Over the years, he established the Sacred Heart, Immaculate Conception, St. Ignatius, Guardian Angel, and Holy Family parishes.

To accommodate their needs along with the growing city population, the Sisters of Charity opened the Hotel Dieu Hospital there in 1894.

[11] The Temple San Ignacio de Loyola was established in El Paso in 1905, and underwent extensive remodeling seven years later.

[14] At the beginning of Schuler's tenure in 1915, the diocese had 31 priests, 22 parishes, 58 missions, nine parochial schools, and three academies to serve 64,440 Catholics.

At the time, El Paso was a major center of the mining industry in the region, with many of the miners being Irish Catholics.

[16][17] During the Mexican Revolution, Schuler provided refuge in El Paso for many clergy, members of religious orders and seminarians fleeing persecution in Mexico.

[8] In the 1930s, the diocese purchased 400 acres of desert property in Sunland Park, New Mexico, for the construction of a 40 statue of Jesus Christ.

[20] During the first few years of his term, with the help of the Catholic Church Extension Society, Metzger travelled the United States making his appeal from the pulpit for funds to erect new apostolates needed by the diocese.

Metzger built the current St. Charles Borromeo Seminary, two Catholic youth organisation camps in the New Mexico mountains, and Holy Cross Retreat near Las Cruces.

In 1972, over 3,000 employees of Farah Manufacturing Company in El Paso went on strike in a work stoppage that lasted 20 months.

At the time, Metzger said, "I feel that the company is acting unjustly in denying to the workers the basic right to collective bargaining."

[21] After Metzger retired in 1978, Pope Paul VI named Auxiliary Bishop Patrick Flores of San Antonio to succeed him.

His replacement in El Paso was Auxiliary Bishop Armando Xavier Ochoa of the Archdiocese of Los Angeles, appointed by the pope in 1996.

In 1999, the diocese began a cooperative program with the Archdiocese of Atlanta for preparing seminarians from Georgia for ministry to the growing Hispanic population.

In January 2019, the Diocese of El Paso released the names of 30 diocesan clergy who were "credibly accused" of committing sexual abuse acts against minors.

[33] Holley was a priest from the Diocese of Worcester living at the Servants of the Paraclete facility in Alamogordo at the time of the alleged crimes.

[33] In August 2020, a woman sued the diocese, claiming that she had been sexually abused by Damian Gamboa, a diocesan priest at the St. Francis de Paula Church in Tularosa, New Mexico, in the early 1980s.

[34] The diocese settled a lawsuit in January 2023 with a man who had alleged being sexually abused in Deming, New Mexico, by Reverd Pedro Martinez from Mt.