[2] Its cathedral episcopal see is Nuestra Señora de la Anunciación, dedicated to Our Lady of the Annunciation, in the city of Guadix, administrative province of Granada.

King Charles IV of Spain founded a hospice in 1803, and the ancient Jesuit college had become a hospital before the early 20th century.

The legend of the Seven Apostolic Men, preserved in the Mozarabic Missal, places the episcopal see of St. Torquatus (bishop from 47), one of the seven, in Ancient Acci, now called Guadix el Viejo, 6 km northwest of the modern city of Guadix, where the matron Luparia built a baptistery and primitive church.

)[4] Liliolus attended the Third Council of Toledo in 589, and the names of the Accitanian bishops are to be found among those who attended the other Toletan councils; Clarencius at the fourth and fifth; Justus at the sixth; Julian at the eighth; Magnarius at the ninth and tenth; and Ricila, the last bishop whose name has come down to us before the Muslim invasion, at subsequent ones.

By right of postliminium, the apostolic rank possessed by the see of Acci previous to the Islamic invasion is attributed to that of Guadix.

Cardinal Pedro González de Mendoza, Archbishop of Toledo, erected the new see of Guadix on 21 May 1492, in virtue of the Apostolic commission of Innocent VIII granted on 4 August 1486.