[10] When Shanahan died in 1886 after 18 years as bishop, the diocese had 51 priests, 51 churches, 75 chapels and missions, three orphanages, 29 parochial schools, and a Catholic population over 35,000.

[11] The second bishop of Harrisburg was Reverend Thomas McGovern of Philadelphia, named by Pope Leo XIII in 1888.

In 1916, Philip R. McDevitt of Philadelphia was appointed the fourth bishop of the Diocese of Harrisburg by Pope Benedict XV.

[16] In 1946, Leech described Howard Hughes’s 1943 film The Outlaw as "a destructive and corrupting picture which glamorizes crime and immorality".

[19] As bishop, Keeler served on a number of committees for interreligious dialogue, and helped expand diocesan youth ministry.

In 1989, Monsignor Nicholas C. Dattilo of Pittsburgh was appointed the eighth bishop of Harrisburg by John Paul II.

[21] As bishop, Dattilo reorganized parishes and missions, because of populations shifts within the fifteen counties of the diocese.

In 2014, Gainer introduced a new policy prohibiting girls at Catholic schools from participating in any wrestling, football, and rugby matches.

[24] It also required male wrestlers from Catholic schools to forfeit matches against female opponents on other teams.

[24] According to the diocese, the ban applies to sports "... that involve substantial and potentially immodest physical contact.

[30] The Diocese of Harrisburg covers the following counties: Adams, Columbia, Cumberland, Dauphin, Franklin, Juniata, Lancaster, Lebanon, Mifflin, Montour, Northumberland, Perry, Snyder, Union and York.

[35] Bach voluntarily retired from ministry and was told to spend the rest of his life in prayer and penance.

Rhoades reported Bach to the police in 2007 and petitioned the Vatican to laicize him, but did not release any information to members of the diocese, fearing a scandal.

When Bishop Donald Trautman of Erie confronted Presley that month, he admitted to sexually abusing the victims.

[38] According to diocesan officials, they had planned a release of a list of priests with credible accusations of sexual abuse in September 2016, but Shapiro asked them to wait until the end of the investigation.

[39][40] According to The Philadelphia Inquirer, the Dioceses of Harrisburg and Greensburg attempted to shut down the grand jury investigation in 2017.

[41][42] In August 2018, the diocese released the names of 71 clergy members accused of sexual abuse of children.

[46] The Pennsylvania grand jury report was released in August 2018, naming 45 clergy from the diocese as having credible accusations of sexual abuse.

[47][48] After the report release, Gainer apologized for the sexual abuse on behalf of the diocese and set up a new website titled Youth Protection Home Page.

[47] In August 2019, diocese officials acknowledged that they had paid $12.1 million to 100 sexual abuse survivors since January of that year.

[54] He is believed to have been removed from priesthood and sent back to his native country of Colombia after sex abuse allegations surfaced against him in 1989 which were related to his time serving in the Diocese of Harrisburg.