Joseph Coutts of the Roman Catholic Archdiocese of Lahore was ordained as Coadjutor Bishop of Hyderabad.

The Golden Jubilee of the diocese was celebrated on 23 August 2007; it had 15 priests serving an estimated 50,000 Catholics.

It provides medical care in Hyderabad and nearby Kotri, and to the tribal people of interior Sindh especially from Mirpurkhas, Tando Allahyar, Tando Adam, Badin, Matli and Nagar Parkar, irrespective of caste or creed.

[8] In 2018 the Diocese welcomed the first nun of the Kacchi Kohli tribe, after 70 years of mission among the tribal peoples in Sindh.

Sister Anita Maryam Mansingh, of the Congregation of the Presentation of the Blessed Virgin Mary (PBVM), took her perpetual vows in Hyderabad in May 2018.

[10] The Spiritans (CSSp), Franciscan Friars Minor (OFM), Mill Hill Missionaries (MHM) and Society of St. Columban (SSC) are also serving in the diocese.

The diocese also runs 6 hostels and boarding schools, particularly catering for the education of the tribal children.