Its name derives from the localities of Medina-Sidonia and Jerez de la Frontera.

This bishopric was erected the 3 of March 1980 by means of a Papal Bull, with the name of Asidonense-Jerezano, in memory of the old Asidonense Bishopric and because its present seat is in Jerez de la Frontera.

The main temple of this diocese the Colegiata of San Salvador, today Jerez's Cathedral.

Juan Grande Roman has like santo pattern from the diocese and like patron to the Immaculate Conception.

It includes Jerez de la Frontera, Sanlúcar de Barrameda, El Puerto de Santa María, Chipiona, Rota, Trebujena, Arcos de la Frontera, Algar, Bornos, Espera, Villamartín, Prado del Rey, El Bosque, Ubrique, Puerto Serrano, Algodonales, Zahara de la Sierra, Benaocaz, Villaluenga del Rosario, Grazalema, El Gastor, Olvera, Alcalá del Valle, Torre Alháquime and Setenil de las Bodegas.