The Roman Catholic Diocese of Keta–Akatsi (Latin: Ketaën(sis)–Akatsien(sis)) is a suffragan Latin diocese in the ecclesiastical province of Accra in Ghana, yet still depends on the missionary Roman Congregation for the Evangelization of Peoples.

The bishops' seat is Christ the King Cathedral, in Akatsi.

The diocese also contains a co-cathedral: St. Michael's Cathedral, in the city of Keta.

As per 2014, it pastorally served 134,600 Catholics (15.4% of 875,000 total) on 7,470 km² in 12 parishes and 6 missions with 55 priests (49 diocesan, 6 religious), 27 lay religious (6 brothers, 21 sisters) and 34 seminarians.

(all Roman rite; until 1976, European missionary members of Latin congregations, when the then auxiliary bishop was appointed as ordinary)