The diocese is led by a prelate bishop who pastors the mother church in the City of Ponce, the Cathedral of Our Lady of Guadalupe.

Its jurisdiction includes the municipalities of Adjuntas, Jayuya, Guánica, Guayanilla, Yauco, Peñuelas, Ponce, Juana Díaz, Villalba, Coamo, Santa Isabel, Salinas, Guayama, Arroyo, and Patillas.

[2] In 1978, Bishop Fremiot Torres Oliver acquired a large property in the Rio Chiquito sector of Barrio Portugués where the Diocese is currently (2019) located.

[7] The See of Ponce was canonically erected on 21 November 1924, and is a suffragan diocese of the Metropolitan Province of San Juan de Puerto Rico.

[8] On 7 September 2018, Judge Edward Godoy ruled that the bankruptcy filed by the Archdiocese of San Juan would also apply to every Catholic diocese in Puerto Rico, including Ponce, and that all would now have their assets protected under Chapter 11.