While the cathedral episcopal see dedicated to the Nativity of Our Lady is at Bang Nok Khwaek, the diocesan center is in the town of Ratchaburi.

The diocese dates back to 30 June 1930, when the Mission sui iuris of Rajaburi was created, originally responsible for the south and west of Thailand, on territory split off from the then Apostolic Vicariate of Bangkok (now its Metropolitan).

The church is built in French Gothic style and decorated with stained glass windows imported from France.

The community grew to about 200 Catholics until 1847, when a first wooden church named Sala Daeng (Red Hall) or Raung Yao (Long Canal) was built near the site of the current cathedral.

In 1890 the French missionary Father Paulo Salmon started construction of the Nativity of Our Lady church, which was inaugurated on 2 February 1896.