It is believed that the first Catholic priest set foot in Singapore in 1821, two years after Stamford Raffles' landing, to attend to the needs of the growing community consisting largely of British colonialists and some Chinese; however, it is probable that there had been Portuguese missionaries operating out of Malacca in Singapore during the Portuguese period, 1511–1641, prior to the British conquest.

Historically (prior to independence in 1965), Catholic communities were divided along racial lines – centred along the entire length of Queen St in town: Conversion to Catholicism among the Chinese community in the 19th century was met with disdain among Chinese immigrant societies in Singapore.

During World War II, in an attempt to manage the growing needs of the local people in Singapore, many Catholics of Eurasian and Chinese ethnicity were deported to Bahau, also aptly called "Fuji Village" at that time, to be self-sufficient in their own food supply.

In 2005, Singapore held an exhibition, dubbed Journey of Faith, on artefacts from Vatican City in the Asian Civilisations Museum at Empress Building, Catholic-oriented artifacts, focusing on art and history, were put on display from June to October 2005.

[6] While at the Changi International Airport, Pope Francis was welcomed in a small reception by Singapore's Minister of Culture, Community and Youth Edwin Tong, Tong's wife and a delegation of government and church officials such as Ambassador of Singapore to the Holy See Ang Janet Guat Har.

[12][13] On 13 September 2024 the pope met elderly and sick residents, as well as staff, of St. Theresa's Home and hold an interreligious meeting with young people at Singapore's Catholic Junior College before departing from the country and returning to Rome.