Contacts between the Italian peninsula and the Armenian Highland go back to the Iron Age when the Etruscan civilization traded with the Kingdom of Urartu by way of Phrygia and Ancient Greece.
The Romans perceiving themselves as the legitimate successors of the Seleucids began to play a more aggressive role in the affairs of the Hellenistic world of Asia Minor starting with the acquisition of Pergamum in 133 BC.
The combined forces of Tigranes and Mithridates were defeated at the Battle of Tigranocerta by the Romans and both monarchs fled to Northern Armenia near the Iberian border.
Frustrated because of the rough terrain of Northern Armenia, Lucullus moved back south and plundered Nisibis which was held by the brother of Tigranes.
This allowed Mithridates to regroup by raising a small army and slaughtering all the Romans in Pontus (two whole legions at Zela alone under the command of Valerius Trianus), he then awaited Median reinforcements from Tigranes at the citadel of Talaura in Lesser Armenia.