Born in Rome, Puppo debuted in 1961 in the Mauro Bolognini's drama Careless, and after a number of very minor roles he soon became a regular of Italian genre cinema in roles of henchmen and villains.

[1] Mainly active in Spaghetti Westerns and Poliziotteschi films, he was also cast as the Paolo Villaggio's antagonist in a number of comedies.

[1] He was hired as Lee Van Cleef's stuntman and double stand-in by director Gianfranco Parolini for his Sabata trilogy, and was one of his pallbearers in 1989.

[2] He served as his stuntman in a number of films including Sabata (1969),[3] Commandos (1968) along Giampiero Albertini,[4][5] and The Good, the Bad and the Ugly (1966) along Benito Stefanelli.

[6] Puppo died in a motor scooter accident while having a heart attack, aged 61.