During May 1995, following a competitive tender, contracts for the line's construction were awarded to a range of contractors that were collectively known as the IRICAV UNO consortium.

During March 2001, it was announced that all civil engineering works had been completed, fulfilling the agreed schedule and with little divergence in terms of costs.

The line is part of Corridor 1 of the European Union's Trans-European high-speed rail network, which connects Berlin and Palermo.

[1] Early on, it was decided that the envisioned construction programme ought to be divided into several lots, covering different sections of the railway's route.

[1] These were put out to competitive tender, during which bidders submitted detailed design specifications for their proposed civil works.

Where deformation phenomena was predicted (or detected), various techniques were employed to stabilise the ground, such as the use of shotcrete, fibre glass structural elements, and additional concrete lining where applicable.

[1] By the end of 1999, approximately 21.6 km (13.4 mi) of tunnel had been completed, roughly equivalent to 99% of the railway's underground sections.

It was the first railway line in Italy to be electrified at 25 kV AC at 50 Hz and the first in the world to use ETCS Level 2 in normal rail operations.

[4] Since opening, the Afragola Station has been typically served by 36 high-speed trains running upon the line, carrying a projected 10,000 passengers, each day; 18 of these being Frecciarossas operated by the state rail company Trenitalia while the other 18 trains are Italos by the privately-owned open access company Nuovo Trasporto Viaggiatori (NTV).

[5] A new interchange with the railway shall be formed at Afragola station following the reconstruction of the Circumvesuviana line, which had been reportedly scheduled for completion in 2022.