It is based in Rome in the monumental complex of Villa Carpegna.
Founded in 1927 by Cipriano Efisio Oppo, artist, writer, member of Parliament and a director of the art trade union, who directed the first four editions of the Quadriennale with the role of "general secretary".
[2] Between 2018 and 2022 Sara Cosulich has been appointed as first artistic director of the history of the institution.
In 2022, under the artistic direction of Gian Maria Tosatti the activity of the institution started switching its main efforts from the production of the quadriennal exhibition to a constant activity of researches, exhibition programs, collaborations with universities and the publishing of magazines and books.
[3] In these last years the institution has begun to collaborate with international curators like Hans Ulrich Obrist[4] or Nadim Samman, or institutions like Fridericianum[5] or Gwangju Biennale.