Green Bay Packers head coach Matt LaFleur, Buffalo Bills running back Fred Jackson, New Orleans Saints quarterback John Fourcade and Pittsburgh Steelers Super Bowl running back Bam Morris, all played in the NIFL.

2003 was the most successful year for the league as 24 teams played a mostly complete schedule, with few cancellations.

Before the 2005 season, nine teams left the league to form United Indoor Football.

For the 2005 season, the NIFL had an agreement with NFL to handle referee assignment and training.

The most notable situation was the owner of the Montgomery Maulers firing the entire team.