On the floating island of Neo Verona, Leontes Montague and his men lead a bloody coup d'état and murder all the members of ruling House Capulet.

Romeo is a kind, caring, selfless and humble man who is opposed to his father's cruelty and tyranny, and shares many ideals with Juliet.

As these starcrossed lovers face many challenges and adventures together, which will strengthen and deepen their true unwavering romantic love even further, an ancient secret hidden deep within Neo Verona is slowly revealed.

The music was composed by Hitoshi Sakimoto and performed by Eminence Symphony Orchestra with Tomohiro Yoshida as sound director.

[3] Romeo × Juliet was also adapted into a manga series, serialized in Kadokawa Shoten's Monthly Asuka shōjo magazine since March 24, 2007.

Theron Martin, of Anime News Network reviewed the first DVD set, and enjoyed the musical score, but felt the story made use of too many 'saved-at-the-last-moment' scenes.

[7] He later chose it as one of the best anime series of 2009, citing Gonzo's preservation of the overall tone, and the addition of "great action" scenes.

[12] He later noted that in the first volume, the use of the fantasy setting was understated but was used more in the second part of the series and enjoyed the "focused" narrative, which he attributes to the "energy and enthusiasm" of the young production team.

[14] He later sums it up by saying, "in spite of its many little faults, it is good, angst-y teenage fun", and that it "doesn't set the world on fire, but there's quite a bit to like about this series".