On 12 August 2012, Oprandi defeated Anna Chakvetadze 5–7, 6–3, 6–3 to win the Bronx Open singles title held in New York.

She reached two WTA Tour semifinals in 2013, in Oeiras and Brussels, but then suffered a shoulder injury which kept her out of action for eight months.

In April 2014, Oprandi reached her first WTA Tour final at the third time of asking by beating top seed Daniela Hantuchová in the semifinals at the Marrakech Grand Prix.

The same day, she won her first WTA Tour doubles title at the same tournament, partnering with Garbiñe Muguruza to defeat Katarzyna Piter and Maryna Zanevska in the final.

Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup and Olympic Games are included in win–loss records.