Some of his colleagues during those formative years were Tony Bongiovi, Bob Clearmountain, Harvey Goldberg, Mike Barbiero, Joe Gastwirt and Michael Brauer.
Since going independent as a producer, engineer and mixer in 1977 his work has amassed over 100 gold and platinum awards, selling well over a quarter billion units, garnering 19 Grammy nominations with 14 wins and numerous American Music and MTV Awards for the artists he has worked with.
He has also mixed live and recorded in venues from CBGB to the 1980 Winter Olympics, Ronald Reagan’s Inauguration Ceremonies and the John F. Kennedy Center for the Performing Arts.
Among some of the most notable artists he has worked with are Jimi Hendrix, Aretha Franklin, Whitney Houston, Diana Ross, Michael Jackson, Smokey Robinson, Ashford & Simpson, Mick Jagger, U2, Muse, Bad Brains, Living Colour, 311, Tool, Soundgarden, Sonic Youth, Creed, The Cure, Ziggy Marley, the Red Hot Chili Peppers, Foreigner, Kraftwerk, Duran Duran, Nels Cline, Ornette Coleman, McCoy Tyner, Jackie McLean, Ben Goldberg, Kris Davis, Craig Taborn, The Last Poets and numerous others.
A large portion of Saint Germain's creative works can be found in motion picture film soundtracks.