Dr. Drakken (voiced by John DiMaggio; portrayed by Todd Stashwick in the live-action film)[13] is a mad scientist and Kim's archenemy.
Shego (voiced by Nicole Sullivan; portrayed by Taylor Ortega in the live-action film)[13] is Dr. Drakken's sidekick and Kim's most dangerous enemy.
She used to be a superheroine alongside her brothers as part of Team Go, as they were hit by a mysterious rainbow "comet" when they were younger and each gained a color-coded glowing superpower; Shego is green-themed and can generate concussive energy blasts.
[16] However, after hearing Nicole Sullivan's performance as Shego, they started to develop her relationship with Drakken, although it is only explicitly identified as a romantic one in the series finale.
[4] He is obsessed with increasing his power through various mystical artifacts and prophecies, and Kim first meets him when he calls her to Cambodia to retrieve a jade monkey idol.
Motor Ed (voiced by John DiMaggio) is Dr. Drakken's cousin, who Mrs. Lipsky considers to be the family's "black sheep", and is known for his repetitive use of the words "Dude" and "Seriously!".
Camille Léon (voiced by Ashley Tisdale) is an heiress and socialite who became a villain after being cut off from her family fortune and gained shapeshifting abilities after having experimental plastic surgery.
Synthodrone #901 (voiced by Raviv Ullman), also known as Eric, is an android created by Dr. Drakken to distract Kim from his plans of world domination.