Born in Montevideo, into a Ticinese family originally from Caslano,[2] Maspoli began playing in the youth ranks of Club Nacional de Football.

He would make his Uruguayan Primera División debut with Liverpool de Montevideo in 1939.

He would spend the rest of his playing career with Peñarol, winning six Primera titles with the club.

[3] In the final match of the 1950 World Cup, known as the "Maracanazo" due to Uruguay's surprising win at the Maracanã stadium in Rio de Janeiro, in front of near 200,000 Brazilian fans, Máspoli allowed one goal as the visitors beat favorites Brazil 2–1.

[4] Máspoli also coached Uruguayan club Peñarol,[5] with which he won five national championships, the Copa Libertadores and the 1966 Intercontinental Cup, when the team beat Real Madrid 4–0 on aggregate.