Roquebrune-sur-Argens (French pronunciation: [ʁɔkbʁyn syʁ aʁʒɑ̃(s)]; Occitan: Ròcabruna d'Argenç) is a commune in the Var department in the Provence-Alpes-Côte d'Azur region, Southeastern France.

The commune consists of the town of Roquebrune-sur-Argens, as well as two smaller villages: La Bouverie north of town and Les Issambres to the south, on the Mediterranean coast.

The commune is home to the French National Water Ski Training Site on the Lac du Vaudois, north of Les Issambres.

The recorded history of the oldest part of the town of Roquebrune-sur-Argens began around 983.

Signs of human settlements, from the local "Bouverian culture", dating from Prehistory, were found in caves near La Bouverie.