Markham followed this up with three more wins in the promotion all via KO/TKO over Brad Blackburn, Marcelo Acevedo, and Keith Wisniewski, respectively, before facing future UFC veteran Chris Wilson at the IFL: Championship Final.

After the demise of the IFL, Markham fought for Adrenaline MMA's inaugural event on June 14, 2008, facing veteran Jay Ellis.

In his next appearance, Markham faced British fighter Dan Hardy at UFC 95 on February 20, 2009, in London, England.

Markham was then expected to face Martin Kampmann at UFC 108 on January 2, 2010, but pulled out due to a knee injury.

This was significant as it was only the second time a fighter training with the Miletich Fighting Systems did not make weight in 15 years.

His films include The Death and Life of Bobby Z with Paul Walker and Laurence Fishburne; The Experiment with Adrien Brody and Forest Whitaker; Setup with Bruce Willis, 50 Cent, and Ryan Phillippe; and Alex Cross with Tyler Perry and Matthew Fox.