She has been a Labor Party member of the Victorian Legislative Assembly since November 2014, representing Yuroke from 2014 to 2022, then Kalkallo from 2022 onwards.
In March 2020, Spence was elevated to the Second Andrews Ministry following the resignation of Gavin Jennings as the Minister for Multicultural Affairs, Community Sport and Youth.
[10] Following the 2022 election, Spence was sworn in as Minister for Prevention of Family Violence, Community Sport and Suburban Development.
[11] Spence is presently the Minister for Agriculture, Community Sport and Carers and Volunteers in the Allan ministry.
Spence has one son and is married to former Victorian Labor assistant state secretary Kos Samaras.