She attended The Catholic University of America (CUA)[5] in Washington, D.C., graduating with a bachelor's degree in fine arts in 1980.

In 2008, Rosanna was named and promoted to anchor of Good Day New York, soon moved alongside Greg Kelly.

On April 29, 2010 Scotto gained some notoriety by suggesting "soy jism" as an alternative name for milk not produced by dairy cattle.

In 1997, Scotto made a cameo appearance as herself on an episode of the Fox police drama New York Undercover.

[9] She also had brief roles in the films, Lisa Picard Is Famous in 2000, Ransom in 1996, The Scout from 1994, the remake of Miracle on 34th Street (also 1994) and Ghostbusters (2016).

[13][14] She is part owner of the family's New York City restaurant, Fresco by Scotto, where she often helps in the kitchen and greets diners.