Closed for passenger services since 1952, it was operated by freight rail transport company Trenes Argentinos Cargas until 2015.

The station served as a terminus of the Córdoba and Rosario Railway company, which laid down its first rails in 1888.

[1][2] The central block of the Rosario station was completely destroyed by a fire on 31 December 1921.

Starting in 2005, the terrains surrounding the station were employed to create an urban park ("Parque Hipólito Yrigoyen").

[3] The station's building was also seat of the Asociación Rosarina Amigos del Riel (Rosario's Friends of the Rail Association), a railway advocacy and research non-profit organization.