The first Rosario derby was played on June 18, 1905; it resulted in a 1–0 win for Newell's Old Boys with a goal from Faustino González.

In 1939 the two clubs were admitted to the Argentine Primera, and the first game at this level resulted in a 1–1 draw on June 18, 1939.

[1] Rosario Central has the edge over Newell's, with 96 wins compared to 77 counting every official encounter.

Newell's Old Boys stepped in to play the game and earned the nickname "Los Leprosos" (The Lepers).

Since the clubs joined the AFA league system in 1939 the top scorers are Edgardo Bauza (Central) and Santiago Santamaría (Newell's), with 9 each.