Our Lady, Queen of the Most Holy Rosary Cathedral is a Roman Catholic church located at 2535 Collingwood Boulevard in the Old West End of Toledo, Ohio.

[1] The building was designed by William Perry of Pittsburgh, Pennsylvania, whose architectural drawings were approved by Samuel Stritch (1921–1930), the second bishop of the diocese of Toledo, Ohio.

The nave of the cathedral is topped by a barrel vault that is divided into seven bays and elaborately painted with figures from both the Old and New Testaments executed by artist Felix Lieftuchter.

The instrument was personally finished by Ernest Skinner, and formally dedicated in 1931 by Palmer Christian, professor of organ at the University of Michigan.

According to the Cathedral Music page on the Holy Rosary Website this fine Skinner organ represents the culmination of his career and reflects the influences of Willis, Cavaille-Coll, and G. Donald Harrison.

In 2000, the cathedral parish completed a restoration of the church interior which removed many decades of soot from coal-fired and oil-fired boilers to return the original brilliance and luster of the mosaic works of art.

In the 2000s, the parish and diocese re-landscaped the grounds, and re-stoned the paths to the entrances of the building to match the theme, style and color of the stonework on the façade.