Roscoe is a village in St. Clair County, Missouri, United States.

The community is on Missouri Route 82 approximately eight miles southwest of Osceola.

There were 81 housing units at an average density of 52.9 per square mile (20.4/km2).

29.4% of all households were made up of individuals, and 11.8% had someone living alone who was 65 years of age or older.

28.6% of all households were made up of individuals, and 16.3% had someone living alone who was 65 years of age or older.

There were 17.5% of families and 19.7% of the population living below the poverty line, including 34.8% of under eighteens and 14.3% of those over 64.