She was previously Chaplain to the Speaker of the House of Commons from 2010 to 2019, having trained with the Church Army before entering parish ministry.

[8] In March 2013, she was installed as a prebendary of St Paul's Cathedral in recognition of "her service to the Church, community and most recently as Chaplain to the Speaker of the House of Commons".

[18] On 19 May 2018, she was one of several religious leaders to lead prayers at the wedding of Prince Harry and Meghan Markle in St George's Chapel, Windsor.

[25] On 6 February 2023, she was appointed an Honorary Bencher of Lincoln's Inn[26] and, on 23 March 2023, she gave the Haberdashers' Golden Lecture at St Bartholomew-the-Less Church in the City of London.

[29] After taking up her parish role in Hackney, Hudson-Wilkin staged a rooftop protest on the church with her curate to highlight the need for funds to repair the fabric of the building.

[31] When she was appointed to the Commons some people alleged that this was an act of political correctness on the part of the speaker, John Bercow.

Ultimately, the traditional role was split in two with Hudson-Wilkin remaining in her Hackney parish and attending the Commons to lead prayer and services at the chapel of St Mary Undercroft, while Andrew Tremlett took up the posts of a Canon of Westminster and rector of St Margaret's, Westminster.

[32] In an interview in The Observer a year after her appointment to the Commons, Hudson-Wilkin commented that she would like to see a more civil attitude among MPs: "That's my secret prayer actually: the world is looking on and I just believe that I would like to see a change there in the way they handle listening to each other and the way they speak to each other.

She has also spoken on the subject of gay marriage, telling The Times that the church is "obsessed with sex" and there are many more important issues.

[16] During her interview on Desert Island Discs, Hudson-Wilkin was asked about the proposed ordination of women as bishops and said: "I believe that we hold certain prejudices about certain things and we believe them to be true ... What I want is for people to be open to the possibilities that their minds might be changed."