[3][4] As a member of the NSW Labor Parliamentary Caucus, Jackson has called on the party to implement drug law reform including the legalisation of cannabis.

She was originally a member of the Sydney University Socialist Left faction, which was an affiliate of the National Organisation of Labor Students (NOLS).

[8][11] For the 2007 Federal Election, Rose was the campaign manager for Labor's Candidate for the marginal Sydney seat of Wentworth, George Newhouse.

The incident attracted significant media coverage because of Jackson's role as a staffer for candidate George Newhouse whose electorate of Wentworth has the highest Jewish population of any in Australia.

[17][18] Jackson served as the National Political Coordinator of left-wing trade union United Voice until 2013, when she moved to a role as a campaign organiser at NSW Labor Office.

[21] As the responsible Shadow Minister, Jackson opposed a motion moved by the NSW Greens which would have temporarily banned the eviction of tenants in coastal communities during the COVID-19 Crisis.

[23] The Coalition Government introduced the Bill in light of the increased use of non-violent direct action by members of Blockade Australia to disrupt logistics infrastructure at Port Botany.

[23] In her Second Reading speech, Jackson argued that the new criminal penalties were necessary "...to target rogue individuals who completely disrupt peak hour traffic on the Spit Bridge, [and] on our ports...".

When asked by presenter Hamish Macdonald about what would be a reasonable price for a two-bedroom flat in Sydney, Jackson initially suggested that such a property could be rented for "a couple of hundred bucks" a week.

[35] In February 2025, Jackson was named as one of the participants in an Australia Day winery tour organised by NSW Transport Minister Jo Haylen, using a taxpayer-funded ministerial car and driver for a 446-kilometre trip.