De Angelis made her film debut at age 41 in Columbia Pictures' For Pete's Sake in 1974.
[2] In 1978, De Angelis was cast as Mrs. D'Amato on the NBC television series The Doctors.
In 1982, she played the recurring role of Millie on CBS' Baker's Dozen.
In 1983, she played a welfare worker in the ABC television movie Enormous Changes at the Last Minute.
In 1985, De Angelis had two leading roles onstage, Vera Vasilyevna in The Nest of the Woodgrouse at the New York Shakespeare Festival and the Kennedy Center, among other venues.