She appeared on Broadway in The Grey-Eyed People (1952), Tonight in Samarkand (1955), Three Men on a Horse (1969), The Prisoner of Second Avenue (1971), and Tribute (1978).

[citation needed] Her father was cellist Milton Prinz, who performed with the NBC Symphony Orchestra and was the founder of the New York String Quartet.

[citation needed] In 1947, at age sixteen, Prinz made her professional acting debut in Dream Girl at the Craigsmoor Summer Theatre.

[3] In 1948, she starred in Cat on a Hot Tin Roof at the Flat Rock Playhouse in North Carolina.

[5] She made her Broadway debut as First Girl Scout in the original production of The Grey-Eyed People, opening on December 17, 1952 at the Martin Beck Theatre.

She was cast in the contract role of Penny Hughes on the CBS soap opera As the World Turns, appearing in the show's first episode on April 2, 1956.

[8] From 1968 to 1969, Prinz played Ella in a touring production of The Apple Tree, co-starring with Tom Ewell.

[16] Prinz only agreed to play the role for six months, on the condition that the show's creator, Agnes Nixon, have the character protest the Vietnam War and support Martin Luther King Jr.[4] In the early 1970s, she appeared in a touring production of Last of the Red Hot Lovers.

[21] Prinz appeared as Maggie Stratton in the original Broadway production of Tribute, co-starring with Jack Lemmon.

[8] In July 1986, Prinz co-starred with Fannie Flagg in a female version of The Odd Couple at the Westport Country Playhouse.

[29] The play had an extended run at the WP Theater and reopened at the Lucille Lortel Theatre during the summer of 1987.

[30] In 1988, Prinz returned to television, playing the recurring role of Sister Mary Joel on the ABC soap opera Ryan's Hope.

[31] In April 1990, she played Evelyn in Tales of the Lost Formicans at New York's Apple Corps Theater.

[35] In December 1996 and January 1997, Prinz played Evelyn in On Deaf Ears at the Martin R. Kaufman Theater in New York.

[40] She played Maria Callas in Master Class at Portland Stage Company in August and September 1998.

[8] She played Maria Callas in Master Class at Connecticut's TheaterWorks in January 2000 and at Florida's Coconut Grove Playhouse in October 2000.

[42][43] Prinz made her film debut in the romantic drama A Wedding for Bella (also titled The Bread, My Sweet), co-starring with Scott Baio.

[8] In September 2001, Prinz co-starred with Mia Dillon in Concertina's Rainbow for Connecticut's Fairfield Theatre Company.

[45][46] From July to August 2002, she co-starred with Laurie Metcalf in Purple Heart for Chicago's Steppenwolf Theatre Company.

[54] Prinz played Mrs. Bramson in Night Must Fall at Maryland's Olney Theatre Center in September and October 2009.

[62] Prinz participated in a live streamed performance of Richard Wilbur's translation of Molière's Tartuffe in July 2020.