Jones has performed stand-up comedy at the Edinburgh Festival Fringe, incorporating her cerebral palsy into her comedic style.

She has also hosted the documentary Am I a R*tard?, the series Trip Hazard: My Great British Adventure, and written an episode of Sex Education.

Jones authored a children's book, The Amazing Edie Eckhart, about an 11-year-old girl with cerebral palsy, and a sequel, The Big Trip.

in English Language and Creative Writing from the University of Huddersfield,[9] Jones was hired for a year as a junior researcher for Objective Media Group as part of a disability scheme at Channel 4.

[10][12] Alongside series creator Laurie Nunn, Jones co-wrote episode four of the second season of the Netflix comedy-drama Sex Education, released in January 2020.

Filmed during the COVID-19 pandemic, it features Jones visiting a number of UK tourist destinations, joined by other celebrities.

[32] In August 2023, it was announced that Jones will play the lead role of Disability Benefits, an upcoming Channel 4 comedy series.

[37] In May 2024, it was announced that Jones would appear as a contestant in the eighteenth series of Taskmaster, alongside Andy Zaltzman, Babatunde Aléshé, Emma Sidi, and Jack Dee.

Jones talks about a hypothetical "able-bodied Rosie" and discusses a sexual fantasy about Ryan Gosling.

[46] In 2019, Jones performed at Spectacular, a one-off event for Comic Relief,[47][48] and appeared at the 2019 Women of the World Festival.

[24]: 21:00 In June 2019, Jones launched a podcast alongside the fellow comedian Helen Bauer, titled Daddy Look at Me.

The titular character, an 11-year-old girl with cerebral palsy, deals with the pressure of entering secondary school and becoming distant from her lifelong friend and support Charlie.

[55] Jones has ataxic cerebral palsy;[56] she incorporates her slow speech pattern into her comedy, constructing jokes to subvert the punchline that audiences expect.

"[10] Jones unexpectedly refers to previous jokes later in her performances, a trait which one critic describes as "clinically planned".

[41] In 2019, Jones received mixed reception for a joke she made on The Last Leg in which she said that as a 16-year-old, environmental activist Greta Thunberg should only be concerned with "drinking Lambrini and getting fingered.

"[58] Jones has spoken on the rights of disabled people, describing bullying that she has experienced and difficulties in her daily life.

[60] During an interview with The Guardian, Jones commented: "I would love in the next few years to see more disabled comedians, directors, producers, commissioners.