The self-ruling Imperial Abbey was secularized in the course of the German mediatization of 1802–1803 and its territory annexed to the Duchy of Württemberg.
In 1221, a branch of a sister community was formed at Hochmauern, south of Rottweil, thus founding the future monastery.
The Abbot of Salem, Eberhard von Rohrdorf, appointed the first Abbess, Williburgis.
Through donations and dowries, the monastery collected land between the Black Forest and Swabian Alb.
In 1898, a mental health institution was set up in the convent rooms, from which today's Vinzenz von Paul Hospital developed.