Rottofreno (Piacentino: Altufrèi, Artufrèi, Ltufrèi or Rtufrèi) is a comune (municipality) in the Province of Piacenza in the Italian region Emilia-Romagna, located about 160 kilometres (99 mi) northwest of Bologna and about 12 kilometres (7 mi) west of Piacenza.

Rottofreno borders the following municipalities: Borgonovo Val Tidone, Calendasco, Chignolo Po, Gragnano Trebbiense, Monticelli Pavese, Piacenza, and Sarmato.

The main settlement of the comune is San Nicolò, which has more inhabitants than Rottofreno proper.

[4] According to a legend, the name (meaning "broken bit") derives from an event during the Carthaginian invasion of Italy (218–201 BC), when Hannibal allegedly broke here the bit of his horse.

In reality the name is from the Lombard roth ("glory") and fridu ("friendship", "safeness").