The hospital was founded by Bartholomew Mosse, a surgeon and midwife who was appalled at the conditions that pregnant women had to endure, in George's Lane in March 1745.

[5] Lying-in is an archaic term for childbirth (referring to the month-long bed rest prescribed for postpartum confinement).

[6] The venture was very successful and Mosse raised money through concerts, exhibitions and even a lottery to establish larger premises.

[10] Open to the public, it provided a healthy income to the hospital annually, Dr. Mosse successfully encouraging wealthy Protestant Dubliners to attend service there.

[26] A medical negligence award was approved in 2020 for a young boy who developed cerebral palsy as a result of complications with his delivery at the hospital in 2004.