LocalLink 22 is a bus route operated by the Maryland Transit Administration in Baltimore.

The line currently operates between the Mondawmin Metro Subway Station and Bayview Medical Center, serving Television Hill, the Woodberry Light Rail Stop, Hampden, The Rotunda, Homewood, Johns Hopkins University, Waverly, Belair-Edison, and Highlandtown.

34 streetcar started operating, known then as the Highlandtown Short Line.

In 2006, as part of the Greater Baltimore Bus Initiative, the frequency of service on Route 22 was nearly doubled at most times to provide improved crosstown service,[5] though the route of the line was not changed.

[6] Part of the route of Route 22 is described in Journeys to the heart of Baltimore By Michael Olesker, in reference to where various ethnic groups board and depart, though the number 22 is not mentioned.