It started operating in 2000 as an experiment conducted by MTA to provide a new type of service.

At that time, service operated every 17 minutes in order to match light rail frequencies.

[2][3] The line operates on portions of the route also covered by routes 22 and 27, but connects to various points of interest in the Hampden area, and to the Woodberry Light Rail Stop.

In 2005, as part of the Greater Baltimore Bus Initiative, a comprehensive overhaul plan for the region's transit system, it was initially proposed that the Hampden Shuttle would be completely eliminated due to low ridership and a heavy cost to taxpayers.

[4] However, after community meetings, it was ultimately decided that it would continue operating with no schedule change.