Roxana Brusso was born in Lima, Peru with a Peruvian, Italian, and Spanish background.
When she was four years old, her family moved to the United States, and she grew up in North Hollywood, California.
After that, she has appeared in several television series like Melrose Place, Beverly Hills 90210, Crossing Jordan, Without a Trace, ER, and NCIS, among others.
In 2007, she landed a recurring role as Maria on the short lived ABC series Dirty Sexy Money.
After the show was cancelled, Brusso went on another recurring role as Detective Alicia Fernández on TNT's cop drama Southland.