She made her debut in the Palme d'Or-winning 2009 film The White Ribbon[1][2] and was since seen in movies, series and on stage, acting in English, French and German.
In 2024 she starred in AMC's series Interview with the vampire from showrunner Rolin B. Jones and appeared 2024 in Gianluca Jodice's movie The Flood.
From the medieval drama Michael Kohlhaas with Mads Mikkelsen, to the comedy La famille Bélier (original idea for the oscar nominated movie CODA) and Mrs Harris Goes to Paris with Isabelle Huppert and Leslie Manville, Duran also played in the horror movie Eight For Silver by Sean Ellis.
Roxane Duran starred in Riviera, a Sky Atlantic series created by Neil Jordan, where she played Adriana Clios for two season.
She performed on stage for the first time in 2012 as the lead in the play Le journal d'Anne Frank by Eric Emmanuel Schmitt.