[1] The parish church was elevated into a cathedral[2] following the creation of the Diocese of Capiz on January 27, 1951.

The church and parish of Roxas City (then named as Municipality of Capiz) is one of the oldest in Panay Island,[3] having been founded by Augustinian missionaries in 1707.

[2][4] The cathedral, as it was in its first inception, is in the historic center of Roxas City and fronts the city plaza, opposite the Panay River and the Capiz Bridge.

From 1918 to 1920, Gabriel Reyes, (who became Bishop of Cebu in 1932 and Archbishop of Manila in 1949) served as its parish priest.

[3][5] In the November 28, 2020, consistory, Archbishop Jose Lazaro Fuerte Advincula became the first Archbishop of Capiz to be created as a cardinal but received his red biretta and ring from Archbishop Charles John Brown, the Apostolic Nuncio to the Philippines, only on June 18, 2021, at the cathedral.