It was also one of nine constituencies in the South of Scotland electoral region, which elects seven additional members, in addition to nine constituency MSPs, to produce a form of proportional representation for the region as a whole.

The other eight constituencies of the South of Scotland region were: Ayr, Carrick, Cumnock and Doon Valley, Clydesdale, Cunninghame South, Dumfries, East Lothian, Galloway and Upper Nithsdale and Tweeddale, Ettrick and Lauderdale.

[1] The Holyrood constituency covered an eastern portion of the Scottish Borders council area.

The rest of the council area was covered by the Tweeddale, Ettrick and Lauderdale constituency, which also covered a western portion of the Midlothian council area.

Following its First Periodic review of constituencies to the Scottish Parliament, the Boundary Commission for Scotland recommended that the Roxburgh and Berwickshire seat be expanded to form the newly shaped Ettrick, Roxburgh and Berwickshire constituency in time for the 2011 election.