Roxburgh and Berwickshire was a county constituency of the House of Commons of the Parliament of the United Kingdom (Westminster) from 1983 to 2005.

The constituency was defined by the Third Periodical Review of the Boundary Commission for Scotland, and first used in the 1983 general election.

The name of the constituency relates it to the Roxburgh and Berwickshire districts of the Borders region, which were created in 1975, under the Local Government (Scotland) Act 1973.

By the time of the Third Periodical Review, Scottish counties and burghs had been abolished by the same legislation which created regions and districts, and earlier constituencies had been defined by the Second Periodical Review, with reference to county and burgh boundaries, results being implemented for the February 1974 general election.

When the constituency was abolished, as a result of the Fifth Periodical Review, Berwickshire, Roxburgh and Selkirk was created, and first used in the 2005 general election, as one of six constituencies covering the Dumfries and Galloway, Scottish Borders, and South Lanarkshire council areas.