On May 29, 2010, Roy Halladay of the Philadelphia Phillies pitched the twentieth perfect game in Major League Baseball history, against the Florida Marlins in Sun Life Stadium.

In his second major league start, on September 27, 1998, he carried a no-hitter into the 9th inning against the Detroit Tigers before giving up a two-out home run to Bobby Higginson.

On Opening Day, Halladay pitched seven innings while giving up a run against the Washington Nationals in his first game with the Phillies.

Halladay pitched his first shutout in the National League, against the Atlanta Braves on April 21, becoming the first pitcher to reach four wins in the 2010 season.

On May 1, Halladay pitched his second shutout of the season, limiting division rival New York Mets to three hits and striking out six.

[4] Roy Halladay pitched the 20th perfect game in MLB history, retiring all 27 batters, and allowing no hits, no runs, and no errors.

The unearned run came in the top of the third, when Chase Utley's line drive bounced off the glove of Florida center fielder Cameron Maybin, allowing Wilson Valdez to score from first.

[5] In the bottom of the ninth, pinch hitter Mike Lamb flied out deep to Shane Victorino in center field for the first out.

The ball would have been a home run in many other ballparks, but did not carry out of Sun Life Stadium's cavernous center field.

[14] Scott Franzke and Larry Andersen were sitting in the booth next to McCarthy and Wheeler, narrating the game for radio.

[15] Unlike television broadcasts, radio play-by-play announcers like Franzke did not subscribe to the superstition of refraining to mention a potential no-hitter or perfect game.

[7] They came to know about the perfect game from Mike Emrick, Eddie Olczyk, and Pierre McGuire when the network replayed the final out during the second period.

He received a standing ovation when he returned to the clubhouse and proceeded to thank catcher Carlos Ruiz for calling the game.

First baseman Ryan Howard retrieved the game ball from the final out to give to Halladay, while the Marlins presented him with the plate from the pitcher's mound.

Some Blue Jays, like reliever Casey Janssen, told reporters that they would offer Halladay in-person congratulations when the team came to Citizens Bank Park the next month.

[21] Halladay also received a congratulatory phone call from Joe Biden, a lifelong Phillies fan and then-Vice President of the United States.

[24] After pitching his perfect game, Halladay commissioned around 60 Baume & Mercier wrist watches that he subsequently gifted to all active roster members of the Phillies, as well as the coaching staff, all clubhouse personnel (including at least one batboy), training and video staff, and public relations officials for the team.

[27] When the Phillies played the Cincinnati Reds in the 2010 National League Division Series, Halladay was called to start Game 1, his first career postseason appearance.

[30] Halladay's postseason effort was the first no-hitter in the history of Citizens Bank Park, and it was the first time that the Phillies had no-hit the Reds since Rick Wise pitched in 1971.

[37] By the end of the year, the MLB league-wide batting average was the lowest that it had been since 1992, and pitchers had thrown five official no-hitters or perfect games—six, with the inclusion of Galarraga.

[39] On May 10, 2011, Halladay pitched a complete game loss when Omar Infante reached home on an error in the eighth inning.

[40] On April 11, 2012, Johnson, who had not won a game in nearly a year, allowed five runs in the third inning to clear the way for a 7–1 Phillies victory.

[42] Shortly after midnight on November 7, 2017, Halladay died when the ICON A5 plane that he had been flying crashed into the Gulf of Mexico, off the coast of Florida.