Roy Orchard Woodruff (March 14, 1876 – February 12, 1953) was a politician and soldier from the U.S. state of Michigan.

He enlisted as a corporal in Company G, Thirty-third Regiment, Michigan Volunteer Infantry, during the Spanish–American War.

Woodruff graduated from the dental department of the Detroit College of Medicine in 1902 and practiced dentistry in Bay City from 1902 to 1911.

Woodruff and William J. MacDonald (12th district) were the only two Michiganders elected to the U.S. House from the Progressive Party.

He was not a candidate for re-nomination in 1914 and served for two years in the First World War as an Infantry officer, acquiring the rank of major during his service in France.